Teloni F, Michelena J, Lezaja A, Kilic S, Ambrosi C, Menon S, Dobrovolna J, Imhof R, Janscak P, Baubec T, Altmeyer M
Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability
Mol Cell. 2018 Dec 24. pii: S1097-2765(18)31006-2.



Altmeyer M
Cells take a break when they are TIARed
EMBO Rep. 2018 Dec 11. pii: e47403. doi: 10.15252/embr.201847403.


Klusmann I, Wohlberedt K, Magerhans A, Teloni F, Korbel JO, Altmeyer M, Dobbelstein M
Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication
PNAS published ahead of print November 9, 2018


Przetocka S, Porro A, Bolck HA, Walker C, Lezaja A, Trenner A, von Aesch C, Himmels SF, D’Andrea AD, Ceccaldi R, Altmeyer M, Sartori AA
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
Mol Cell. 2018 Nov 1;72(3):568-582.e6.


Michelena J, Lezaja A, Teloni F, Schmid T, Imhof R, Altmeyer M
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Nat Commun. 2018 Jul 11;9(1):2678.
Lezaja A, Altmeyer M
High Content Imaging für Multidimensionale Zellanalysen
BIOspektrum. 03/2018


Altmeyer M
The memory remains
Aging (Albany NY). 2018 Mar 29. doi: 10.18632/aging.101408.



Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Hoff Backe P, Pellegrino S, Raymond FL, Froyen G, Altmeyer M, Bjørås M, Dianov GL, van Loon B
Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability
Sci Rep. 2017 Nov 8;7(1):15050.


Lezaja A, Altmeyer M
Inherited DNA lesions determine G1 duration in the next cell cycle
Cell Cycle. 2017 Oct 5:0. doi: 10.1080/15384101.2017.1383578.


Michelena J, Altmeyer M
Cell Cycle Resolved Measurements of Poly(ADP-Ribose) Formation and DNA Damage Signaling by Quantitative Image-Based Cytometry
Methods Mol Biol. 2017;1608:57-68.


Pellegrino S, Michelena J, Teloni F, Imhof R, Altmeyer M
Replication-Coupled Dilution of H4K20me2 Guides 53BP1 to Pre-replicative Chromatin
Cell Reports 19, 1819–1831, 2017



Duda H, Arter M, Gloggnitzer J, Teloni F, Wild P, Blanco MG, Altmeyer M, Matos J
A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis
Developmental Cell 39, 740–755, December 19, 2016


Mangerich A, Altmeyer M
Identifying ADP-ribosylation targets by chemical genetics
Translational Cancer Research. 2016 doi: 10.21037/tcr.2016.11.06.


Ochs F, Somyajit K, Altmeyer M, Rask MB, Lukas J, Lukas C
53BP1 fosters fidelity of homology-directed DNA repair
Nat Struct Mol Biol. 2016 Jun 27. doi: 10.1038/nsmb.3251.


Andersson A, Bluwstein A, Kumar N, Teloni F, Traenkle J, Baudis M, Altmeyer M, Hottiger MO
PKCα and HMGB1 antagonistically control hydrogen peroxide-induced poly-ADP-ribose formation
Nucleic Acids Res. 2016 May 19. pii: gkw442.

Full Text Article

Pellegrino S, Altmeyer M
Interplay between ubiquitin, SUMO and poly(ADP-ribose) in the cellular response to genotoxic stress
Front. Genet., 19 April 2016 |

Full Text Article

Aguzzi A, Altmeyer M
Phase Separation: Linking Cellular Compartmentalization to Disease
Trends in Cell Biol. 2016 DOI:


Ahuja AK, Jodkowska K, Teloni F, Bizard AH, Zellweger R, Herrador R, Ortega S, Hickson ID, Altmeyer M, Mendez J, Lopes M
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Nature Comm. 2016 Feb 15. doi:10.1038/ncomms10660

Full Text Article

Teloni F, Altmeyer M
Readers of poly(ADP-ribose): designed to be fit for purpose
Nucleic Acids Res. 2016 Feb 18;44(3):993-1006.

Full Text Article



Lukas J, Altmeyer M
A lncRNA to repair DNA
EMBO Rep. 2015 Nov;16(11):1413-4.

Full Text Article
Comment on: Sharma V, et al. EMBO Rep. 2015 Sep 27. pii: e201540437.


Altmeyer M, Neelsen, KJ, Teloni F, Pozdnyakova I, Pellegrino S, Grofte M, Rask MB, Streicher W, Jungmichel S, Nielsen ML, Lukas J
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
Nature Comm. 2015 Aug 19;6:8088



Larsen DH, Hari F, Clapperton JA, Gwerder M, Gutsche K, Altmeyer M, Jungmichel S, Toledo LI, Fink D, Rask MB, Grøfte M, Lukas C, Nielsen ML, Smerdon SJ, Lukas J, Stucki M
The NBS1-Treacle complex controls ribosomal RNA transcription in response to DNA damage
Nat Cell Biol. 2014 Aug;16(8):792-803

Full Text Article


Altmeyer M, Lukas J
Guarding against collateral damage during chromatin transactions
Cell 2013;153(7):1431-4

Full Text Article


Altmeyer M, Lukas J
To spread or not to spread–chromatin modifications in response to DNA damage
Curr Opin Genet Dev 2013;23(2):156-65

Full Text Article


Altmeyer M, Toledo L, Gudjonsson T, Grøfte M, Rask MB, Lukas C, Akimov V, Blagoev B, Bartek J, Lukas J
The chromatin scaffold protein SAFB1 renders chromatin permissive for DNA damage signaling
Mol Cell 2013;52(2):206-20

Full Text Article
Highlighted in SAFB1 Regulates the Chromatin Response to DNA Damage. Cancer Discovery 2013;3

Jungmichel S, Rosenthal F, Altmeyer M, Lukas J, Hottiger MO, Nielsen ML
Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses
Mol Cell 2013;52(2):272-85

Full Text Article
Received the cover image of Mol Cell. 2013 Oct 24;52(2).


Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
Cell 2013;155(5):1088-103

Full Text Article
Highlighted in Naked Replication Forks Break apRPArt. Cell 2013;155(5):979:980
Highlighted in Exhaustion of RPA Leads to Replication Catastrophe. Cancer Discovery 2014;4:16


Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
Cell 2012;150(4):697-709

Full Text Article
Highlighted in DNA damage response: Restricting repair. Nat Rev Mol Cell Biol 2012;13(10):601
Highlighted in New ligases join the ubiquitylation cascade in repair. Nat Cell Biol 2012;14:990
Highlighted in TRIP12 and UBR5 Prevent Ubiquitin Spreading at Damaged Loci. Cancer Discovery 2012;2

Altmeyer M
Addicted to PAR? A closer look at PARP inhibitor sensitivity
Cell Cycle. 2012 Nov 1;11(21):3916

Full Text Article
Comment on: Oplustilova L, et al. Cell Cycle. 2012 Oct 15;11(20):3837-50.


Asher G, Reinke H, Altmeyer M, Gutierrez-Arcelus M, Hottiger MO, Schibler U
Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding
Cell 2010;142(6):943-53

Full Text Article
Highlighted in Circadian rhythms: PARP1 feeds into clocks. Nat Rev Mol Cell Biol 2010;11(11):754-5
Highlighted in PARP around the clock. Cell 2010;142(6):841-3

Toller IM, Altmeyer M, Kohler E, Hottiger MO, Müller A
Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia
Cancer Res. 2010 Jul 15;70(14):5912-22

Full Text Article
Highlighted in: Issues in Cancer Epidemiology and Research: 2011 Edition. ISBN: 978-1-4649-6353-7

Messner S, Altmeyer M, Zhao H, Pozivil A, Roschitzki B, Gehrig P, Rutishauser D, Huang D, Caflisch A, Hottiger MO
PARP1 ADP-ribosylates lysine residues of the core histone tails
Nucleic Acids Res. 2010 Oct;38(19):6350-62.

Full Text Article
Highlighted as top 5% Featured Article by Nucleic Acids Res.


Altmeyer M, Barthel M, Eberhard M, Rehrauer H, Hardt WD, Hottiger MO
Absence of poly(ADP-ribose) polymerase 1 delays the onset of Salmonella enterica serovar Typhimurium-induced gut inflammation
Infect Immun. 2010 Aug;78(8):3420-31.

Full Text Article


Altmeyer M, Messner S, Hassa PO, Fey M, Hottiger MO
Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
Nucleic Acids Res 2009;37(11):3723-38

Full Text Article


Altmeyer M, Hottiger MO
Poly(ADP-ribose) polymerase 1 at the crossroad of metabolic stress and inflammation in aging
Aging (Albany NY). 2009 May 20;1(5):458-69

Full Text Article


Timinszky G, Till S, Hassa PO, Hothorn M, Kustatscher G, Nijmeijer B, Colombelli J, Altmeyer M, Stelzer EH, Scheffzek K, Hottiger MO, Ladurner AG
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Nat Struct Mol Biol. 2009 Sep;16(9):923-9

Full Text Article
Highlighted in Kraus WL. New functions for an ancient domain. Nat Struct Mol Biol. 2009 Sep;16(9):904-7.

Messner S, Schuermann D, Altmeyer M, Kassner I, Schmidt D, Schär P, Müller S, Hottiger MO
Sumoylation of poly(ADP-ribose) polymerase 1 inhibits its acetylation and restrains transcriptional coactivator function
FASEB J. 2009 Nov;23(11):3978-89

Full Text Article


Haenni SS, Altmeyer M, Hassa PO, Valovka T, Fey M, Hottiger MO
Importin alpha binding and nuclear localization of PARP-2 is dependent on lysine 36, which is located within a predicted classical NLS
BMC Cell Biol. 2008 Jul 21;9:39

Full Text Article

Haenni SS, Hassa PO, Altmeyer M, Fey M, Imhof R, Hottiger MO
Identification of lysines 36 and 37 of PARP-2 as targets for acetylation and auto-ADP-ribosylation
Int J Biochem Cell Biol. 2008;40(10):2274-83.

Full Text Article


Fahrer J, Kranaster R, Altmeyer M, Marx A, Bürkle A
Quantitative analysis of the binding affinity of poly(ADP-ribose) to specific binding proteins as a function of chain length
Nucleic Acids Res. 2007;35(21):e143.

Full Text Article