As part of an active scientific community that studies the DNA damage response (DDR) and its impact on cancer and aging, research in the lab of Matthias Altmeyer is aimed at elucidating cellular mechanisms of genome integrity maintenance and their deregulation in human disease. Here you can explore who we are and what we do. Welcome!

Efficient pre-mRNA cleavage protects from stress

Phase separation of DNA repair compartments

Our newest research article has just been published in EMBO Journal and is currently among the most read papers there. We show that DNA repair compartments marked by 53BP1 have liquid-like properties and provide insights into specificity and function of phase separation.

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Efficient pre-mRNA cleavage protects from stress

Efficient pre-mRNA cleavage protects from stress

In our recent publication in Molecular Cell we uncover that the pre-mRNA cleavage factor WDR33 protects cells from replication stress. We propose that pre-mRNA cleavage is needed to release nascent mRNAs from the genome and thereby prevent topological problems during replication.

Publications

Postdoctoral Candidates and MSc/PhD Students

Postdoctoral Candidates and MSc/PhD Students

We are always looking for motivated postdoctoral researchers and/or MSc/PhD students to join our lab. If you are interested in chromatin dynamics and genome stability and have a liking for quantitative cell biology, please take a look at our open positions.

Current Openings

Featured News


Article published in Molecular Cell

February 2019

Replication stress is a hallmark of many cancers. In an article published in the February 2019 issue of Molecular Cell (Volume 73, Issue 4, p641-858) we identify the pre-mRNA cleavage factor WDR33 as regulator of replication stress resilience and demonstrate that, when WDR33 function is impaired, unreleased nascent transcripts and genomic loci re-localize toward the nuclear periphery, where they cause replication stress and DNA damage.

Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability

Further reading:

Teloni et al. Mol Cell. 2019 Feb 21;73(4):670-683.e12


Measuring cellular responses to PARP inhibition

July 2018

Our paper on PARP inhibitor toxicity is published in Nature Communications! Have a look how high-content imaging reveals the earliest cellular responses to PARP inhibition and unravels the sequence of events from PARP trapping to DNA damage, cell cycle arrest and cell death. Here you can access the complete article and browse through theĀ Editors’ Highlights, or read the UZH/EurekAlert public releases.

Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Further reading:

Michelena et al. Nat Commun. 2018 Jul 11;9(1):2678.


Lab research featured in UZH Magazin and in the Annual Report 2017

March 2018

Research of the group brought to life by Roland Fischer and photographer Marc Latzel for UZH Magazin 01/2018 (UZH News). Download the full article or the complete magazine (in German). Read the English translation here.

Our work was also included in the UZH Annual Report 2017. Download the complete Annual Report or have a look at the online summary.


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