As part of an active scientific community that studies the DNA damage response (DDR) and its impact on cancer and aging, research in the lab of Matthias Altmeyer is aimed at elucidating cellular mechanisms of genome integrity maintenance and their deregulation in human disease. Here you can explore who we are and what we do. Welcome!

DSB Repair Pathway Choice During S-phase

Article finally out in Methods in Molecular Biology

Our lab contributed a chapter to the Second Edition of “Poly(ADP-Ribose) Polymerase: Methods and Protocols”, edited by Alexei V. Tulin. Check out how automated microscopy can be used for cell cycle resolved measurements of poly(ADP-ribose) formation.

Read the article

DSB Repair Pathway Choice During S-phase

DSB Repair Pathway Choice During S-phase

Read how the DNA damage response utilizes replication-coupled dilution of a histone mark, H4K20me2, to guide BRCA1’s antagonist 53BP1 to pre-replicative chromatin and thereby facilitate the choice between NHEJ and HR during S-phase progression.

Publications

Postdoctoral Candidates and PhD Students

Postdoctoral Candidates and PhD Students

Motivated applications from postdoctoral researchers with a strong interest in genome stability or chromatin biology and willing to apply for fellowships are always encouraged. PhD students are recruited through the Life Science Zurich Graduate School.

Current Openings

UA-67564934-1