As part of an active scientific community that studies the DNA damage response (DDR) and its impact on cancer and aging, research in the lab of Matthias Altmeyer is aimed at elucidating cellular mechanisms of genome integrity maintenance and their deregulation in human disease. Here you can explore who we are and what we do. Welcome!
Federico receives prestigious Mercator Award
Federico Teloni, who recently defended his PhD thesis in our lab, receives the UZH Mercator Award 2019 in the category Natural Sciences & Medicine. The prestigious award honours the findings from his PhD work and his overall outstanding achievements.
Our newest paper on PARP inhibitor toxicity is published in Nature Communications! Check how high-content imaging reveals the earliest cellular responses to PARP inhibition and unravels the sequence of events from PARP trapping to DNA damage, cell cycle arrest and cell death.
We are always looking for motivated postdoctoral researchers and/or MSc/PhD students to join our lab. If you are interested in chromatin dynamics and genome stability and have a liking for quantitative cell biology, please take a look at our open positions.
Replication stress is a hallmark of many cancers. In an article published in the February 2019 issue of Molecular Cell (Volume 73, Issue 4, p641-858) we identify the pre-mRNA cleavage factor WDR33 as regulator of replication stress resilience and demonstrate that, when WDR33 function is impaired, unreleased nascent transcripts and genomic loci re-localize toward the nuclear periphery, where they cause replication stress and DNA damage.
Our paper on PARP inhibitor toxicity is published in Nature Communications! Have a look how high-content imaging reveals the earliest cellular responses to PARP inhibition and unravels the sequence of events from PARP trapping to DNA damage, cell cycle arrest and cell death. Here you can access the complete article and browse through the Editors’ Highlights, or read the UZH/EurekAlert public releases.
Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance
Lab research featured in UZH Magazin and in the Annual Report 2017
Research of the group brought to life by Roland Fischer and photographer Marc Latzel for UZH Magazin 01/2018 (UZH News). Download the full article or the complete magazine (in German). Read the English translation here.