As the University of Zurich resumes on-site operations with applicable safety concepts in place also our lab resumes experimental work, albeit with reduced capacity and with safety precautions.
In a recent publication we identified the chromatin remodeler CHD7 as a novel component of the DNA damage response. After PAR-dependent recruitment CHD7 plays a role upstream of DNA end resection to fix broken DNA.
We have openings for a postdoctoral researcher and a PhD student to join our lab. If you are interested in cancer biology and genome integrity maintenance and have a liking for quantitative cell biology, please get in touch.
August 2020
We show that the ubiquitin E3 ligase TRIP12, through its PAR-binding WWE domain, targets PARP1 for proteasomal degradation, affecting PARP functions and PARP inhibitor efficiency. Great work with important implications worth following up. Congratulations to Marco Gatti and big thanks to our collaborators Qingyao Huang and Michael Baudis for their help. Published in Cell Reports.
Gatti et al., Cell Rep. 2020 Aug 4;32(5):107985.
July 2019
Spearheaded by Matteo Berti from Massimo Lopes’ group and Federico Teloni from our lab, our collaborative study on RAD51 and replication fork reversal is finally out in Nature Communications.
Berti, Teloni et al., Nat Commun. 2020 Jul 15;11(1):3531.
August 2019
The DNA damage response factor and chromatin binder 53BP1 generates repair compartments around DNA breaks. In a paper published in EMBO Journal (2019)38:e101379 we show that these nuclear compartments show liquid-like properties, exhibit induced self‐assembly based on 53BP1’s oligomerization potential, and undergo fusion and fission events with potential implications for break clustering and chromosomal translocations. 53BP1 condensates are sensitive to disruption of weak interactions, and can co-assemble and contribute to the activation of tumor suppressor protein p53. See also the News & Views by Piccinno et al.
Kilic et al., EMBO J (2019)38:e101379
February 2019
Replication stress is a hallmark of many cancers. In an article published in the February 2019 issue of Molecular Cell (Volume 73, Issue 4, p641-858) we identify the pre-mRNA cleavage factor WDR33 as regulator of replication stress resilience and demonstrate that, when WDR33 function is impaired, unreleased nascent transcripts and genomic loci re-localize toward the nuclear periphery, where they cause replication stress and DNA damage.
Teloni et al. Mol Cell. 2019 Feb 21;73(4):670-683.e12
July 2018
Our paper on PARP inhibitor toxicity is published in Nature Communications! Have a look how high-content imaging reveals the earliest cellular responses to PARP inhibition and unravels the sequence of events from PARP trapping to DNA damage, cell cycle arrest and cell death. Here you can access the complete article and browse through the Editors’ Highlights, or read the UZH/EurekAlert public releases.
Michelena et al. Nat Commun. 2018 Jul 11;9(1):2678.
March 2018
Research of the group brought to life by Roland Fischer and photographer Marc Latzel for UZH Magazin 01/2018 (UZH News). Download the full article or the complete magazine (in German). Read the English translation here.
Our work was also included in the UZH Annual Report 2017. Download the complete Annual Report or have a look at the online summary.
