Our newest research article has been published by the EMBO Journal and is among the most read papers there. We show that DNA repair compartments marked by 53BP1 have liquid-like properties and provide insights into specificity and function of phase separation.
In our recent publication in Molecular Cell we uncover that the pre-mRNA cleavage factor WDR33 protects cells from replication stress. We propose that pre-mRNA cleavage is needed to release nascent mRNAs from the genome and thereby prevent topological problems during replication.
We have openings for a postdoctoral researcher and MSc/PhD students to join our lab. If you are interested in cancer biology and genome integrity maintenance and have a liking for quantitative cell biology, please take a look at our open positions.
February 2019
Replication stress is a hallmark of many cancers. In an article published in the February 2019 issue of Molecular Cell (Volume 73, Issue 4, p641-858) we identify the pre-mRNA cleavage factor WDR33 as regulator of replication stress resilience and demonstrate that, when WDR33 function is impaired, unreleased nascent transcripts and genomic loci re-localize toward the nuclear periphery, where they cause replication stress and DNA damage.
Teloni et al. Mol Cell. 2019 Feb 21;73(4):670-683.e12
July 2018
Our paper on PARP inhibitor toxicity is published in Nature Communications! Have a look how high-content imaging reveals the earliest cellular responses to PARP inhibition and unravels the sequence of events from PARP trapping to DNA damage, cell cycle arrest and cell death. Here you can access the complete article and browse through the Editors’ Highlights, or read the UZH/EurekAlert public releases.
Michelena et al. Nat Commun. 2018 Jul 11;9(1):2678.
March 2018
Research of the group brought to life by Roland Fischer and photographer Marc Latzel for UZH Magazin 01/2018 (UZH News). Download the full article or the complete magazine (in German). Read the English translation here.
Our work was also included in the UZH Annual Report 2017. Download the complete Annual Report or have a look at the online summary.
